Prof. Dr. Jochen Staiger
Director of the Department of Neuroanatomy
![[Translate to Englisch:] Prof. Dr. Jochen F. Staiger](/fileadmin/_processed_/b/b/csm_Staiger_2140a8ce2e.jpg)
Prof. Dr. Jochen F. Staiger
University Medical Center Göttingen
Center of Anatomy
Department of Neuroanatomy
Kreuzbergring 36
D-37075 Göttingen
Phone: +49 551 3967051
E-mail: jochen.staiger(at)med.uni-goettingen.de
| Jahr / Year | |
|---|---|
| January 2011 | Founding member of the Collaborative Research Center 889 Cellular mechanisms of sensory processing (Project C3: Integration of afferent sensory and cortical input by identified neurons of the rodent somatosensory cortex) |
| April 2010 | Full Professor of Neuroanatomy and Director of the Department of Neuroanatomy (Center Anatomy) at the Georg-August-University Göttingen |
| January 2007 | Founding member of the Collaborative Research Center 780 Synaptic mechanisms of neural network function (Project C1: Topographic maps and their synaptic circuits in modular and nonmodular (disorganized) rodent barrel cortex) |
| March 2006 | Associate Professor of Cell Biology (Institute of Anatomy and Cell Biology, Department of Neuroanatomy) at the Albert-Ludwigs-University Freiburg |
| November 2003 | Junior Research Award of the Northrhine-Westfelian Academy of Science-initiative „Neurovisionen“ |
| May 2002 | Assistant Professor (C2-Hochschuldozenten) |
| December 2000 | Habilitation and Venia legendi for Anatomy at the Medical Faculty of the Heinrich-Heine-University Düsseldorf |
| March 1998 | Fachanatom – Anatomische Gesellschaft |
| June 1994 - present | Post-doc at the C. & O. Vogt-Institute for Brain Research, Düsseldorf, (Head: Prof. Dr. K. Zilles) |
| Feb. - June 1994 | Scholarship holder of the German Research Council at the laboratory of Dr. T. F. Freund, KOKI, Institute of Experimental Medicine, Dept. of Functional Neuroanatomy |
| January 1993 | Graduation as MD (Dr. med.) at the Medical Faculty of the Justus-Liebig-University Giessen; grade: summa cum laude |
| 1992 - 1994 | Internship at the Department of Neurology at the University Düsseldorf(Head: Prof. Dr. H.-J. Freund) |
| Feb. - March 1990 | Scholarship holder of the European Science Foundation at the laboratory of Dr. F. G. Wouterlood at the Free University of Amsterdam |
| Aug. - Okt. 1989 | Visiting fellow at the laboratory of Prof. L.C.H. Wang, Dept. Zoology, Edmonton, Canada |
| Feb. - March 1989 | Visiting fellow at the laboratory of Dr. F. G. Wouterlood at the Free University of Amsterdam |
| 1987 - 1990 | Experimental studies at the Justus-Liebig-University Giessen at the Institute of Anatomy and Cell Biology (Head: Prof. A. Oksche) |
Research focus
My scientific interest lies in the functional logic of the wiring blueprint of the cortical column. This basic module of the cortex cerebri (also called macrocolumn) appears to have enough “computational power” to be able to carry out important functions in sensory stimulus processing. However, there is increasing evidence that the functionality of the cortex cannot be understood with the sole concept of the cortical column and the “canonical circuit” integrated into it, as more and more non-canonical circuit motifs are being found.
The approximately 9,000 excitatory and inhibitory neurons in a barrel-associated column in the mouse are of very different morphological types. Both the excitatory pyramidal cells and the inhibitory (GABAergic) interneurons can be divided into further subtypes, which each have typical input-output patterns depending on their membership in the different cortical layers. A key distinguishing feature for GABAergic interneurons is the subcellular target cell specificity, which roughly divides them into 2 classes for (i) output (spiking) control and (ii) input (dendritic integration) control: the first includes the parvalbumin-expressing axo-axonic (or Chandelier) cells and basket cells as “perisomatic inhibitors”, the second involves (amongst others) the somatostatin-expressing Martinotti cells, the VIP-expressing bipolar interneurons and the NDNF-expressing neuroglial cells as “dendritic inhibitors”.
Publications
2023
Direction selectivity of inhibitory interneurons in mouse barrel cortex differs between interneuron subtypes.
Julien Guy, Martin Möck, Jochen F. Staiger.
Cell Reports 42, 111936; doi.org/10.1016/j.celrep.2022.111936, 2023.
Abstract
2022
Repetitively burst-spiking neurons in reeler mice show conserved but also highly variable morphological features of layer Vb-fated “thick-tufted” pyramidal cells.
Jochen F. Staiger*, Alexandra Sachkova, Martin Möck, Julien Guy and Mirko Witte.
Front. Neuroanat. 16:1000107. doi: 10.3389/fnana.2022.1000107, 2022.
Abstract
BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain.
Huong Nguyen, Godwin Sokpor, Arpan Parichha, Linh Pham, Nidhi Saikhedkar, Yuanbin Xie, Pauline Antonie Ulmke, Joachim Rosenbusch, Mehdi Pirouz, Rüdiger Behr, Anastassia Stoykova, Beate Brand-Saberi, Huu Phuc Nguyen, Jochen F. Staiger, Shubha Tole and Tran Tuoc.
Front. Cell Dev. Biol. 10:1011109. doi: 10.3389/fcell.2022.1011109, 2022.
Abstract
2021
Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons.
Ricardo Martins Merino, Leon-Pinzon, Walter Stühmer, Martin Möck, Jochen F. Staiger, Fred Wolf, Andreas Neef.
Proceedings of the National Academy of Science USA 2021 118 (51) e2114549118, 2021.
Abstract
Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity.
Anastassios Karagiannis, Thierry Gallopin, Alexandre Lacroix, Fabrice Plaisier, Juliette Piquet, Hélène Geoffroy, Régine Hepp, Jérémie Naudé, Benjamin Le Gac, Richard Egger, Bertrand Lambolez, Dongdong Li, Jean Rossier, Jochen F Staiger, Hiromi Imamura, Susumu Seino, Jochen Roeper, Bruno Cauli.
eLife 2021;10:e71424, 2021.
Abstract
H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion.
Aemil Kerimoglu, Linh Pham, Anton B. Tonchev, M. Sadman Sakib, Yuanbin Xie, Godwin Sokpor, Pauline Antonie Ulmke, Lalit Kaurani, Eman Abbas, Huong Nguyen, Joachim Rosenbusch, Alexandra Michurina, Vincenzo Capece, Meglena Angelova, Nenad Maricic, Beate Brand-Saberi, Miriam Esgleas, Mareike Albert, Radoslav Minkov, Emil Kovachev, Ulrike Teichmann, Rho H. Seong, Wieland B. Huttner, Huu Phuc Nguyen, Anastassia Stoykova, Jochen F. Staiger, Andre Fischer, Tran Tuoc.
Science Advances 2021; 7 : eabc6792, 2021.
Abstract
Conditional Loss of BAF (mSWI/SNF) Scaffolding Subunits Affects Specification and Proliferation of Oligodendrocyte Precursors in Developing Mouse Forebrain.
Eman Abbas, Mohamed A Hassan, Godwin Sokpor, Kamila Kiszka, Linh Pham, Cemil Kerimoglu, Andre Fischer, Huu Phuc Nguyen, Jochen F Staiger, Tran Tuoc.
Front Cell Dev Biol. 2021 Jul 15;9:619538., 2021.
Abstract
Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.
Godwin Sokpor, Cemil Kerimoglu, Huong Nguyen, Linh Pham, Joachim Rosenbusch, Robin Wagener, Huu Phuc Nguy, Andre Fischer, Jochen F. Staiger
and Tran Tuoc.
Front. Mol. Neurosci., 16 June 2021 | doi.org/10.3389/fnmol.2021.687581, 2021.
Abstract
Mapping of domain-mediated protein-protein interaction by SPOT peptide assay.
Xiaoyi Mao, Godwin Sokpor, Jochen F Staiger, Huu Phuc Nguyen, Tran Tuoc.
STAR Protocols, Volume 2, Issue 2, 100503, 2021.
Abstract
Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex.
Godwin Sokpor, Joachim Rosenbusch, Ajaya J Kunwar, Michael Rickmann, Tran Tuoc, Silvio O Rizzoli, Victor Tarabykin, Gabriele Fischer von Mollard, Kerstin Krieglstein, Jochen F Staiger.
Neuroscience . 2021 May 21;463:303-316. doi: 10.1016/j.neuroscience.2021.03.021. Epub 2021 Mar 26, 2021.
Abstract
Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex.
Pauline Antonie Ulmke, M Sadman Sakib, Peter Ditte, Godwin Sokpor, Cemil Kerimoglu, Linh Pham, Yuanbin Xie, Xiaoyi Mao, Joachim Rosenbusch, Ulrike Teichmann, Huu Phuc Nguyen, Andre Fischer, Gregor Eichele, Jochen F Staiger, Tran Tuoc.
Stem Cell Reports 2021 Apr 13;16(4):968-984, 2021.
Abstract
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling.
Pauline Antonie Ulmke, Yuanbin Xie, Godwin Sokpor, Linh Pham, Orr Shomroni, Tea Berulava, Joachim Rosenbusch, Uttiya Basu, Andre Fischer, Huu Phuc Nguyen, Jochen F. Staiger, Tran Tuoc.
Development 2021 148: dev188276 doi: 10.1242/dev.188276, 2021.
Abstract
Spine dynamics of PSD-95-deficient neurons in the visual cortex link silent synapses to structural cortical plasticity.
Rashad Yusifov, Anja Tippmann, Jochen F. Staiger, Oliver M. Schlüter and Siegrid Löwel.
Proceedings of the National Academy of Science USA, 2021 118 (10) e2022701118, 2021.
Abstract
Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex.
Nora Jamann, Dominik Dannehl, Nadja Lehmann, Robin Wagener, Corinna Thielemann, Christian Schultz, Jochen F. Staiger, Maarten H. P. Kole & Maren Engelhardt.
Nature Communications 12:23; doi.org/10.1038/s41467-020-20232-x, 2021.
Abstract
Neuronal Circuits in Barrel Cortex for Whisker Sensory Perception.
Staiger JF and Petersen CCH.
Physiological Reviews 101:353-415, 2021.
Abstract
2020
NKCC-1 mediated Cl− uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs.
Sergey N. Kolbaev, Namrata Mohapatra, Rongqing Chen, Aniello Lombardi, Jochen F. Staiger, Heiko J. Luhmann, Peter Jedlicka & Werner Kilb.
Scientific Reports volume 10, Article number: 18399, 2020.
Abstract
Increased Callosal Connectivity in Reeler Mice Revealed by Brain-Wide Input Mapping of VIP Neurons in Barrel Cortex.
Georg Hafner, Julien Guy, Mirko Witte, Pavel Truschow, Alina Rüppel, Nikoloz Sirmpilatze, Rakshit Dadarwal, Susann Boretius, Jochen F Staiger.
Cerebral Cortex, bhaa280, doi.org/10.1093/cercor/bhaa280, 2020.
Abstract
A community-based transcriptomics classification and nomenclature of neocortical cell types.
Rafael Yuste, Michael Hawrylycz, Nadia Aalling, Argel Aguilar-Valles, Detlev Arendt, Ruben Armananzas Arnedillo, Giorgio A. Ascoli, Concha Bielza, Vahid Bokharaie, Tobias Borgtoft Bergmann, Irina Bystron, Marco Capogna, Yoonjeung Chang, Ann Clemens, Christiaan P. J. de Kock, Javier DeFelipe, Sandra Esmeralda Dos Santos, Keagan Dunville, Dirk Feldmeyer, Richárd Fiáth, Gordon James Fishell, Angelica Foggetti, Xuefan Gao, Parviz Ghaderi, Natalia A. Goriounova, Onur Güntürkün, Kenta Hagihara, Vanessa Jane Hall, Moritz Helmstaedter, Suzana Herculano, Markus M. Hilscher, Hajime Hirase, Jens Hjerling-Leffler, Rebecca Hodge, Josh Huang, Rafiq Huda, Konstantin Khodosevich, Ole Kiehn, Henner Koch, Eric S. Kuebler, Malte Kühnemund, Pedro Larrañaga, Boudewijn Lelieveldt, Emma Louise Louth, Jan H. Lui, Huibert D. Mansvelder, Oscar Marin, Julio Martinez-Trujillo, Homeira Moradi Chameh, Alok Nath, Maiken Nedergaard, Pavel Němec, Netanel Ofer, Ulrich Gottfried Pfisterer, Samuel Pontes, William Redmond, Jean Rossier, Joshua R. Sanes, Richard Scheuermann, Esther Serrano-Saiz, Staiger JF, Peter Somogyi, Gábor Tamás, Andreas Savas Tolias, Maria Antonietta Tosches, Miguel Turrero García, Hermany Munguba Vieira, Christian Wozny, Thomas V. Wuttke, Liu Yong, Juan Yuan, Hongkui Zeng & Ed Lein.
Nature Neuroscience 23: 1456–1468, 2020.
Abstract
Histological assessment of optogenetic tools to study fronto-visual and fronto-parietal cortical networks in the rhesus macaque.
Fortuna, M. G. Huer, J. Guo, H. Gruber, J. Gruber-Dujardin, E. Staiger, J. F. Scherberger, H. Treue, S. Gail, A..
Scientific Reports: 10(1)2020: DOI 10.1038/s41598-020-67752-6, 2020.
Abstract
Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits.
Simanaviciute U, Ahmed J, Brown RE, Connor-Robson N, Farr TD, Fertan E, Gambles N, Garland H, Morton AJ, Staiger JF, Skillings EA, Trueman RC, Wade-Martins R, Wood NI, Wong AA, Grant RA.
J Neurosci Methods. 2020 Feb 1;331:108532. doi: 10.1016/j.jneumeth.2019.108532., 2020.
Abstract
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